Previous evidence connects periodontal disease, a modifiable condition affecting a majority of Americans, with metabolic and cardiovascular morbidity and mortality. This review focuses on the likely mediation of these associations by immune activation and their potential interactions with mental illness. Future longitudinal, and ideally interventional studies, should focus on reciprocal interactions and cascading effects, as well as points for effective preventative and therapeutic interventions across diagnostic domains to reduce morbidity, mortality and improve quality of life.

中文翻译：

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牙周、代谢和心血管疾病：探索炎症和心理健康的作用

先前的证据将牙周病（一种影响大多数美国人的可改变疾病）与代谢和心血管疾病的发病率和死亡率联系起来。本综述重点关注免疫激活对这些关联的可能中介作用及其与精神疾病的潜在相互作用。未来的纵向和理想的介入性研究应侧重于相互作用和级联效应，以及跨诊断领域的有效预防和治疗干预点，以降低发病率、死亡率和提高生活质量。