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Diagnoses of Pathological States Based on Acetylcholinesterase and Butyrylcholinesterase.
Current Medicinal Chemistry ( IF 4.1 ) Pub Date : 2020-05-31 , DOI: 10.2174/0929867326666190130161202
Miroslav Pohanka 1
Affiliation  

Two cholinesterases exist: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). While AChE plays a crucial role in neurotransmissions, BChE has no specific function apart from the detoxification of some drugs and secondary metabolites from plants. Thus, both AChE and BChE can serve as biochemical markers of various pathologies. Poisoning by nerve agents like sarin, soman, tabun, VX, novichok and overdosing by drugs used in some neurodegenerative disorders like Alzheimer´s disease and myasthenia gravis, as well as poisoning by organophosphorus pesticides are relevant to this issue. But it appears that changes in these enzymes take place in other processes including oxidative stress, inflammation, some types of cancer and genetically conditioned diseases. In this review, the cholinesterases are introduced, the mechanism of inhibitors action is explained and the relations between the cholinesterases and pathologies are explained.



中文翻译:

基于乙酰胆碱酯酶和丁酰胆碱酯酶的病理状态诊断。

存在两种胆碱酯酶:乙酰胆碱酯酶(AChE)和丁酰胆碱酯酶(BChE)。尽管AChE在神经传递中起着至关重要的作用,但BChE除了对某些药物和植物中的次生代谢产物进行解毒外,没有任何特定功能。因此,AChE和BChE均可作为各种病理学的生化标志物。神经毒剂如沙林,梭曼,塔布恩,VX,novichok中毒以及某些神经退行性疾病(如阿尔茨海默氏病和重症肌无力)中所用药物的过量使用以及有机磷农药中毒均与该问题有关。但似乎这些酶的变化发生在其他过程中,包括氧化应激,炎症,某些类型的癌症和遗传疾病。在这篇评论中,介绍了胆碱酯酶,

更新日期:2020-05-31
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