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Compact intermediates in RNA folding.
Annual Review of Biophysics ( IF 12.4 ) Pub Date : 2010-01-01 , DOI: 10.1146/annurev.biophys.093008.131334
Sarah A Woodson 1
Affiliation  

Large noncoding RNAs fold into their biologically functional structures via compact yet disordered intermediates, which couple the stable secondary structure of the RNA with the emerging tertiary fold. The specificity of the collapse transition, which coincides with the assembly of helical domains, depends on RNA sequence and counterions. It determines the specificity of the folding pathways and the magnitude of the free energy barriers to the ensuing search for the native conformation. By coupling helix assembly with nascent tertiary interactions, compact folding intermediates in RNA also play a crucial role in ligand binding and RNA-protein recognition.

中文翻译:

RNA折叠中的紧凑中间体。

大型非编码 RNA 通过紧凑但无序的中间体折叠成其生物学功能结构,这将 RNA 的稳定二级结构与新兴的三级折叠相结合。塌陷转变的特异性与螺旋结构域的组装一致,取决于 RNA 序列和反离子。它决定了折叠途径的特异性和随后寻找天然构象的自由能障碍的大小。通过将螺旋组装与新生的三级相互作用耦合,RNA 中的紧凑折叠中间体在配体结合和 RNA 蛋白质识别中也起着至关重要的作用。
更新日期:2010-05-12
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