A better hygiene, a Westernized diet, air pollution, climate changes, and other factors that influence host microbiota, a key player in the induction and maintenance of immunoregulatory circuits and tolerance, are thought to be responsible for the increase of allergic diseases observed in the last years. The increase of allergic diseases in elderly is related to the presence of other factors as several comorbidities that should interfere with the development and the type of allergic reactions. A central role is played by immunosenescence responsible for modifying response to microbiota and triggering inflamm-ageing. In addition, in elderly there is a shift from Th1 responses vs. Th2, hence favouring allergic responses. Better understanding of the mechanisms of immunosenescence and its effects on allergic inflammation will most certainly lead to improved therapy.

中文翻译：

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老年人过敏性疾病的免疫和非免疫机制：生物学和临床特征。

人们认为，更好的卫生条件，西餐饮食习惯，空气污染，气候变化以及其他影响宿主微生物的因素，宿主微生物在诱导和维持免疫调节回路及耐受性中起着关键作用，这是导致过敏性疾病增加的原因。去年。老年人过敏性疾病的增加与其他因素的存在有关，因为一些合并症会干扰过敏反应的发展和类型。免疫衰老在调节微生物群的反应并触发炎症老化方面起着核心作用。此外，在老年人中，Th1反应与Th2反应有所不同，因此倾向于过敏反应。