Vitamin D fortified foods (VDFs) were taken into consideration due to the high prevalence of osteoporosis worldwide. However, the efficacy of VDFs on bone health has not been fully examined. The current meta-analysis was conducted in order to summarize the impacts of VDFs on serum 25-hydroxyvitamin D (25(OH)D), bone mineral density (BMD), and bone turnover markers (BTM). A systematic search up to October 2017 was done via PubMed and Scopus search engines. To pool mean differences, random-effects model (the DerSimonian-Laird estimator) was used. Heterogeneity among studies was examined by Cochrane Q test. 20 trials involving 1786 subjects were included in this meta-analysis. Based on random effect model, there were significant effects of VDFs on serum 25(OH)D (MD:16.94 nmol/L 95% CI: 13.38, 20.50; p < 0.001, I2 = 99.0%), BMD (MD: 0.03 gr/cm2; 95% CI: (0.02, 0.05); p < 0.001, I2 = 58.8%) and paratormone hormone (PTH; MD:-9.22; 95% CI: (-14.97, -3.46); p = 0.002, I2 = 98.8%). VDFs may increase serum 25(OH)D and BMD while decrease serum PTH levels. We did not find any beneficial effect of VDFs on BTM.

中文翻译：

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维生素D强化食品对骨矿物质密度和血清骨生物标志物的功效：干预研究的系统评价和荟萃分析。

由于全世界骨质疏松症的患病率很高，因此考虑了维生素D强化食品（VDF）。但是，VDF对骨骼健康的功效尚未得到充分检查。为了总结VDF对血清25-羟基维生素D（25（OH）D），骨矿物质密度（BMD）和骨转换标记（BTM）的影响，进行了当前的荟萃分析。截至2017年10月，通过PubMed和Scopus搜索引擎进行了系统搜索。为了合并均值差异，使用了随机效应模型（DerSimonian-Laird估计量）。研究之间的异质性通过Cochrane Q检验进行了检验。这项荟萃分析包括20项涉及1786名受试者的试验。基于随机效应模型，VDF对血清25（OH）D有显着影响（MD：16.94 nmol / L 95％CI：13.38，20.50; p <0.001，I2 = 99.0％），BMD（MD：0.03 gr / cm2; 95％CI：（0.02，0.05）; p <0.001，I2 = 58.8％）和帕拉托蒙激素（PTH； MD：-9.22； 95％CI：（-14.97，-3.46）； p = 0.002，I2 = 98.8％）。VDF可增加血清25（OH）D和BMD，同时降低血清PTH水平。我们没有发现VDF对BTM有任何有益作用。