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Targeting gut microbiota with dietary components on cancer: Effects and potential mechanisms of action.
Critical Reviews in Food Science and Nutrition ( IF 10.2 ) Pub Date : 2019-01-11 , DOI: 10.1080/10408398.2018.1555789
Jun Tao 1 , Sha Li 2 , Ren-You Gan 3 , Cai-Ning Zhao 1 , Xiao Meng 1 , Hua-Bin Li 1, 4
Affiliation  

Cancers are common chronic diseases worldwide and cause severe health burdens. There have been ongoing debates on the role of gut microbiota in the prevention and management of cancers, thus, it is worthwhile to pay high attention to the impacts of gut microbiota on several cancers, such as colon, liver, and breast cancers. In addition, it has been reported that gut microbiota may also affect the efficacy of cancer chemotherapy and immunotherapy. Among all the factors that influence gut microbiota, diet is the most influential and modifiable. The prebiotics, dietary fibers, short-chain fatty acids, and other bioactive compounds are all important dietary components to assist the growth of beneficial microbiota in the gut, which can protect against cancers and promote human health. Their beneficial effects can be due to the fermentation of dietary fibers, the metabolism of phytochemicals, the synthesis of estrogens, and interactions with chemotherapies and immunotherapies. In order to provide updated information of the relationships among dietary components, gut microbiota, and cancer, in this review, we summarize the reciprocal interactions between dietary components and gut microbiota, and highlight the impacts of dietary components on several common cancers by targeting gut microbiota, with the potential mechanisms of actions also intensively discussed. As a result, this review can be very helpful for healthy people as well as cancer patients to prevent or manage cancers via dietary factor-mediated regulation of gut microbiota.

中文翻译:

以饮食成分为目标的肠道菌群对癌症的影响和作用机制。

癌症是全世界常见的慢性疾病,会造成严重的健康负担。关于肠道菌群在预防和控制癌症中作用的争论一直在进行,因此,值得高度关注肠道菌群对几种癌症的影响,例如结肠癌,肝癌和乳腺癌。另外,据报道肠道菌群也可能影响癌症化学疗法和免疫疗法的功效。在影响肠道菌群的所有因素中,饮食是最有影响力和可修改的。益生元,膳食纤维,短链脂肪酸和其他生物活性化合物都是重要的饮食成分,有助于肠道中有益微生物群的生长,从而可以预防癌症并促进人类健康。它们的有益作用可能是由于膳食纤维的发酵,植物化学物质的代谢,雌激素的合成以及与化学疗法和免疫疗法的相互作用。为了提供饮食成分,肠道菌群与癌症之间关系的最新信息,在本综述中,我们总结了饮食成分与肠道菌群之间的相互关系,并通过针对肠道菌群来突出饮食成分对几种常见癌症的影响。 ,还深入讨论了潜在的行动机制。结果,该评论对于健康人以及癌症患者通过饮食因子介导的肠道菌群调节来预防或管理癌症非常有用。以及与化学疗法和免疫疗法的相互作用。为了提供饮食成分,肠道菌群与癌症之间关系的最新信息,在本综述中,我们总结了饮食成分与肠道菌群之间的相互关系,并通过针对肠道菌群来突出饮食成分对几种常见癌症的影响。 ,还深入讨论了潜在的行动机制。结果,该评论对于健康人以及癌症患者通过饮食因子介导的肠道菌群调节来预防或管理癌症非常有用。以及与化学疗法和免疫疗法的相互作用。为了提供饮食成分,肠道菌群与癌症之间关系的最新信息,在本综述中,我们总结了饮食成分与肠道菌群之间的相互关系,并通过针对肠道菌群来突出饮食成分对几种常见癌症的影响。 ,还深入讨论了潜在的行动机制。结果,该评论对于健康人以及癌症患者通过饮食因子介导的肠道菌群调节来预防或管理癌症非常有用。我们总结了饮食成分与肠道菌群之间的相互相互作用,并通过针对肠道菌群突出了饮食成分对几种常见癌症的影响,并对潜在的作用机制也进行了深入讨论。结果,该综述对于健康人以及癌症患者通过饮食因子介导的肠道菌群调节来预防或管理癌症非常有用。我们总结了饮食成分与肠道菌群之间的相互相互作用,并通过针对肠道菌群突出了饮食成分对几种常见癌症的影响,并对潜在的作用机制也进行了深入讨论。结果,该评论对于健康人以及癌症患者通过饮食因子介导的肠道菌群调节来预防或管理癌症非常有用。
更新日期:2020-03-02
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