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Myeloid Cell Nuclear Differentiation Antigen (MNDA) Positivity in Primary Follicles
Applied Immunohistochemistry & Molecular Morphology ( IF 1.6 ) Pub Date : 2020-05-01 , DOI: 10.1097/pai.0000000000000738
Vidhya Manohar 1 , Raheem Peerani , Brent Tan , Dita Gratzinger , Yasodha Natkunam
Affiliation  

Supplemental Digital Content is available in the text. Myeloid cell nuclear differentiation antigen (MNDA) is an immunohistochemical marker that is used to distinguish marginal zone lymphomas (MZLs) from other small B-cell lymphomas. An index case that showed MNDA staining in primary follicles prompted the current study to evaluate whether MNDA expression is widespread in primary follicles and to address whether it poses a potential diagnostic pitfall. Of the 15 cases with primary follicles identified by a search of the laboratory information system, 7 had positive MNDA staining. In all cases, there was weak nuclear staining similar to what is typical of MNDA staining in MZLs. All cases showed intense nuclear signal in myeloid lineage cells such as neutrophils, which served as positive internal controls. The histologic and cytologic features of primary follicles and MZLs showed overlapping features, particularly in small biopsies. Our results indicate that weak nuclear MNDA staining can act as a potential pitfall in the evaluation of small B-cell lymphomas. Correlation with other immunohistochemical markers that are useful in the workup of small B-cell lymphomas, as well as those that outline immunoarchitectural features of lymphoid follicles, is suggested when both entities are part of the differential diagnosis. Our results underscore the need for caution in the interpretation of weak nuclear MNDA staining in the evaluation of small B-cell lymphomas.

中文翻译:

初级卵泡中髓样细胞核分化抗原 (MNDA) 阳性

补充数字内容在文本中可用。髓样细胞核分化抗原 (MNDA) 是一种免疫组织化学标志物,用于区分边缘区淋巴瘤 (MZL) 和其他小 B 细胞淋巴瘤。一个显示初级卵泡中 MNDA 染色的指示病例促使当前的研究评估 MNDA 表达是否在初级卵泡中广泛存在,并解决它是否构成潜在的诊断陷阱。在通过实验室信息系统搜索确定的 15 例具有初级卵泡的病例中,7 例 MNDA 染色呈阳性。在所有情况下,都存在类似于 MZL 中典型的 MNDA 染色的弱核染色。所有病例均在髓系细胞(如中性粒细胞)中显示出强烈的核信号,作为阳性内部对照。初级卵泡和 MZL 的组织学和细胞学特征显示出重叠的特征,尤其是在小活检中。我们的结果表明,弱核 MNDA 染色可能是评估小 B 细胞淋巴瘤的潜在陷阱。当两个实体都属于鉴别诊断的一部分时,建议与可用于小 B 细胞淋巴瘤检查的其他免疫组织化学标志物以及概述淋巴滤泡免疫结构特征的那些免疫组织化学标志物相关联。我们的结果强调了在评估小 B 细胞淋巴瘤时对弱核 MNDA 染色的解释需要谨慎。我们的结果表明,弱核 MNDA 染色可能是评估小 B 细胞淋巴瘤的潜在陷阱。当两个实体都属于鉴别诊断的一部分时,建议与可用于小 B 细胞淋巴瘤检查的其他免疫组织化学标志物以及概述淋巴滤泡免疫结构特征的那些免疫组织化学标志物相关联。我们的结果强调了在评估小 B 细胞淋巴瘤时对弱核 MNDA 染色的解释需要谨慎。我们的结果表明,弱核 MNDA 染色可能是评估小 B 细胞淋巴瘤的潜在陷阱。当两个实体都属于鉴别诊断的一部分时,建议与可用于小 B 细胞淋巴瘤检查的其他免疫组织化学标志物以及概述淋巴滤泡免疫结构特征的那些免疫组织化学标志物相关联。我们的结果强调了在评估小 B 细胞淋巴瘤时对弱核 MNDA 染色的解释需要谨慎。
更新日期:2020-05-01
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