Drugs that block voltage-gated sodium channels are efficacious in the management of neuropathic pain. Accordingly, this class of ion channels has been a major focus of analgesic research both in academia and in the pharmaceutical/biotechnology industry. In this article, we review the history of the use of sodium channel blockers, describe the current status of sodium channel drug discovery, highlight the challenges and hurdles to attain sodium channel subtype selectivity, and review the potential usefulness of selective sodium channel blockers in neuropathic pain.

中文翻译：

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用于治疗神经性疼痛的钠通道阻滞剂。

阻断电压门控钠通道的药物可有效治疗神经性疼痛。因此，这类离子通道一直是学术界和制药/生物技术行业镇痛研究的主要焦点。在本文中，我们回顾了钠通道阻滞剂的使用历史，描述了钠通道药物发现的现状，突出了实现钠通道亚型选择性的挑战和障碍，并回顾了选择性钠通道阻滞剂在神经病中的潜在用途。疼痛。