Naftopidil ((±)-1-[4-(2-methoxyphenyl) piperazinyl]-3-(1-naphthyloxy) propan-2-ol) is prescribed in several Asian countries for lower urinary tract symptoms suggestive of benign prostatic hyperplasia. Previous animal experiments showed that intrathecal injection of naftopidil abolished rhythmic bladder contraction in vivo. Naftopidil facilitated spontaneous inhibitory postsynaptic currents in substantia gelatinosa (SG) neurons in spinal cord slices. These results suggest that naftopidil may suppress the micturition reflex at the spinal cord level. However, the effect of naftopidil on evoked excitatory postsynaptic currents (EPSCs) in SG neurons remains to be elucidated.

中文翻译：

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高浓度的萘甲托地尔对明胶质神经元的背根诱发兴奋性突触传递的影响。

在一些亚洲国家/地区，对于某些提示存在良性前列腺增生的下尿路症状，规定了萘甲地尔（（±）-1- [4-（2-甲氧基苯基）哌嗪基] -3-（1-萘氧基）丙-2-醇）。先前的动物实验表明，鞘内注射那夫多地在体内消除了节律性膀胱收缩。Naftopidil促进脊髓切片中明胶质（SG）神经元的自发抑制突触后电流。这些结果表明，萘哌地尔可能在脊髓水平抑制排尿反射。然而，那夫托地尔对SG神经元诱发的兴奋性突触后电流（EPSC）的影响仍有待阐明。