Presenilins are functionally important components of γ-secretase, which cleaves a number of transmembrane proteins. Manipulations of PSEN1 and PSEN2 have been separately studied in Alzheimer disease (AD) and cancer because both involve substrates of γ-secretase. However, numerous clinical studies have reported an inverse correlation between AD and cancer. Interestingly, AD is a neurodegenerative disorder, whereas cancer is characterized by the proliferation of malignant cells. However, this inverse correlation in the PSEN double-knockout (PSEN dKO) mouse model of AD has been not elucidated, although doing so would shed light onto the relationship between AD and cancer.

中文翻译：

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PSEN双基因敲除小鼠中阿尔茨海默氏病与癌症之间关系的全面MicroRNAome分析。

早老蛋白是γ-分泌酶的功能重要组成部分，γ-分泌酶可裂解许多跨膜蛋白。PSEN1和PSEN2的操纵已在阿尔茨海默病（AD）和癌症中分别进行了研究，因为它们都涉及γ-分泌酶的底物。然而，许多临床研究已经报道了AD与癌症之间的负相关。有趣的是，AD是一种神经退行性疾病，而癌症的特征是恶性细胞的增殖。但是，尚未阐明AD的PSEN双敲除（PSEN dKO）小鼠模型中的这种逆相关性，尽管这样做可以阐明AD与癌症之间的关系。