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Plesiomonas shigelloides Revisited.
Clinical Microbiology Reviews ( IF 36.8 ) Pub Date : 2016-03-11 , DOI: 10.1128/cmr.00103-15
J Michael Janda 1 , Sharon L Abbott 2 , Christopher J McIver 3
Affiliation  

After many years in the family Vibrionaceae, the genus Plesiomonas, represented by a single species, P. shigelloides, currently resides in the family Enterobacteriaceae, although its most appropriate phylogenetic position may yet to be determined. Common environmental reservoirs for plesiomonads include freshwater ecosystems and estuaries and inhabitants of these aquatic environs. Long suspected as being an etiologic agent of bacterial gastroenteritis, convincing evidence supporting this conclusion has accumulated over the past 2 decades in the form of a series of foodborne outbreaks solely or partially attributable to P. shigelloides. The prevalence of P. shigelloides enteritis varies considerably, with higher rates reported from Southeast Asia and Africa and lower numbers from North America and Europe. Reasons for these differences may include hygiene conditions, dietary habits, regional occupations, or other unknown factors. Other human illnesses caused by P. shigelloides include septicemia and central nervous system disease, eye infections, and a variety of miscellaneous ailments. For years, recognizable virulence factors potentially associated with P. shigelloides pathogenicity were lacking; however, several good candidates now have been reported, including a cytotoxic hemolysin, iron acquisition systems, and lipopolysaccharide. While P. shigelloides is easy to identify biochemically, it is often overlooked in stool samples due to its smaller colony size or relatively low prevalence in gastrointestinal samples. However, one FDA-approved PCR-based culture-independent diagnostic test system to detect multiple enteropathogens (FilmArray) includes P. shigelloides on its panel. Plesiomonads produce β-lactamases but are typically susceptible to many first-line antimicrobial agents, including quinolones and carbapenems.

中文翻译:

再谈Plesiomonas shigelloides。

在弧菌科中多年后,由单一物种P. shigelloides代表的假单胞菌属目前存在于肠杆菌科,尽管其最合适的系统发育位置尚待确定。plesiomonads的常见环境水库包括淡水生态系统和河口以及这些水生环境的居民。长期以来一直被怀疑是细菌性肠胃炎的病因,令人信服的证据在过去的20年中以一系列完全或部分归因于志贺氏疟原虫的食源性暴发形式积累了这一结论。志贺氏疟原虫肠炎的患病率差异很大,东南亚和非洲的发病率较高,而北美和欧洲的发病率较低。这些差异的原因可能包括卫生条件,饮食习惯,区域性职业或其他未知因素。志贺氏疟原虫引起的其他人类疾病包括败血病和中枢神经系统疾病,眼部感染以及各种其他疾病。多年来,缺乏与志贺氏假单胞菌致病性相关的可识别毒力因子。但是,现在已经报道了几种好的候选药物,包括细胞毒性溶血素,铁捕获系统和脂多糖。尽管志贺氏疟原虫易于生化鉴定,但由于其菌落较小或在胃肠道样本中的患病率较低,因此在粪便样本中经常被忽略。然而,一种FDA批准的可检测多种肠病原体(FilmArray)的基于PCR的独立于培养物的诊断测试系统,在其面板上包括志贺菌。褶膜单胞菌产生β-内酰胺酶,但通常易受许多一线抗微生物剂的影响,包括喹诺酮和碳青霉烯类。
更新日期:2019-11-01
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