Biobanks are increasingly being established to act as mediators between patient-donors and researchers. In practice, some of these will close. This paper details the experiences of one such bank. We report interviews with the bank's staff and oversight group during the period when the bank ceased biobanking activity, reconfigured as a disseminator of best practice, before then closing altogether. The paper makes three distinct contributions: (i) to provide a detailed account of the establishment, operational challenges, and eventual closure of the bank, which makes clear the rapid turnover in a cycle of promise and disappointment; (ii) to explore this in terms of a novel analytical focus upon field, institutional, and individual expectations; and (iii) to use this typology to demonstrate how, even after the bank's closure, aspects of its work were reconfigured and reused in new contexts. This provides a unique empirical analysis of the under-reported issue of biobank closure.

中文翻译：

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关闭人体组织生物库：在承诺和失望周期中的个人、机构和现场期望

越来越多地建立生物库，以充当患者捐赠者和研究人员之间的中介。在实践中，其中一些将关闭。本文详细介绍了这样一家银行的经验。我们报告了在银行停止生物样本库活动、重新配置为最佳实践传播者、然后完全关闭之前对银行工作人员和监督小组的采访。这篇论文做出了三个不同的贡献：(i) 详细描述了银行的成立、运营挑战和最终关闭，清楚地说明了在承诺和失望的循环中的快速周转；(ii) 从对领域、机构和个人期望的新分析重点来探索这一点；(iii) 使用这种类型来证明即使在银行倒闭之后，其工作的各个方面被重新配置并在新的环境中重新使用。这为生物样本库关闭的报告不足问题提供了独特的实证分析。