Nanomaterials for targeted delivery are uniquely capable of localizing delivery of therapeutics and diagnostics to diseased tissues. The ability to achieve high, local concentrations of drugs or image contrast agents at a target site provides the opportunity for improved system performance and patient outcomes along with reduced systemic dosing. In this review, the design of targeted nanodelivery systems is discussed with an emphasis on in vivo performance, the physicochemical properties that affect localization at the target site, and the incorporation of therapeutic drugs into these systems.

中文翻译：

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药物和诊断的靶向纳米递送

用于靶向递送的纳米材料具有独特的能力，能够将治疗和诊断药物局部递送到患病组织。在目标部位实现高局部药物或成像造影剂浓度的能力为改善系统性能和患者结果以及减少全身剂量提供了机会。在这篇综述中，讨论了靶向纳米递送系统的设计，重点是体内性能、影响靶位点定位的理化特性以及治疗药物纳入这些系统的情况。