This review summarizes the current state-of-the-art of radiolabeled nanoparticles for molecular imaging and internal radiotherapy applications targeting cancer. With the capacity to provide enormous flexibility, radiolabeled nanoparticles have the potential to profoundly impact disease diagnosis and patient management in the near future. Currently, the major challenges facing the research on radiolabeled nanoparticles are desirable (tumor) targeting efficacy, robust chemistry for both radionuclide encapsulation/incorporation and targeting ligand conjugation, favorable safety profile, as well as certain commercial and regulatory hurdles.

中文翻译：

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放射性标记纳米粒子对癌症的分子成像和治疗

这篇综述总结了目前最先进的放射性标记纳米粒子，用于分子成像和针对癌症的内部放射治疗应用。由于能够提供巨大的灵活性，放射性标记的纳米粒子有可能在不久的将来对疾病诊断和患者管理产生深远的影响。目前，放射性标记纳米粒子研究面临的主要挑战是理想的（肿瘤）靶向功效、放射性核素封装/掺入和靶向配体缀合的稳健化学、有利的安全性以及某些商业和监管障碍。