当前位置: X-MOL 学术Fly › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Compromising asymmetric stem cell division in Drosophila central brain: Revisiting the connections with tumorigenesis.
FLY ( IF 1.2 ) Pub Date : 2018-01-08 , DOI: 10.1080/19336934.2017.1416277
Ana Carmena 1
Affiliation  

Asymmetric cell division (ACD) is an essential process during development for generating cell diversity. In addition, a more recent connection between ACD, cancer and stem cell biology has opened novel and highly intriguing venues in the field. This connection between compromised ACD and tumorigenesis was first demonstrated using Drosophila neural stem cells (neuroblasts, NBs) more than a decade ago and, over the past years, it has also been established in vertebrate stem cells. Here, focusing on Drosophila larval brain NBs, and in light of results recently obtained in our lab, we revisit this connection emphasizing two main aspects: 1) the differences in tumor suppressor activity of different ACD regulators and 2) the potential relevance of environment and temporal window frame for compromised ACD-dependent induction of tumor-like overgrowth.



中文翻译:

损害果蝇中枢脑的不对称干细胞分裂:重新探讨与肿瘤发生的联系。

不对称细胞分裂(ACD)是发育过程中产生细胞多样性的重要过程。此外,ACD,癌症和干细胞生物学之间的最新联系为该领域开辟了新颖而引人入胜的场所。十多年前,果蝇神经干细胞(神经母细胞,NBs)首次证明了受损的ACD与肿瘤发生之间的这种联系,并且在过去的几年中,脊椎动物干细胞中也建立了这种联系。在这里,专注于果蝇 幼虫脑NBs,并根据我们实验室最近获得的结果,我们重新研究该连接,着重强调两个主要方面:1)不同ACD调节剂在肿瘤抑制活性上的差异,以及2)环境和时间窗框架对被感染者的潜在相关性ACD依赖性诱导肿瘤样过度生长。

更新日期:2018-01-08
down
wechat
bug