The past decade has seen a dramatic expansion in the number and range of techniques available to obtain genome-wide information and to analyze this information so as to infer both the functions of individual molecules and how they interact to modulate the behavior of biological systems. Here, we review these techniques, focusing on the construction of physical protein-protein interaction networks, and highlighting approaches that incorporate protein structure, which is becoming an increasingly important component of systems-level computational techniques. We also discuss how network analyses are being applied to enhance our basic understanding of biological systems and their disregulation, as well as how these networks are being used in drug development.

中文翻译：

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相互作用组的结构生物信息学。

在过去十年中，可用于获取全基因组信息并分析该信息以推断单个分子的功能以及它们如何相互作用以调节生物系统行为的技术数量和范围急剧扩大。在这里，我们回顾了这些技术，重点是物理蛋白质-蛋白质相互作用网络的构建，并强调了结合蛋白质结构的方法，蛋白质结构正成为系统级计算技术的一个越来越重要的组成部分。我们还讨论了如何应用网络分析来增强我们对生物系统及其失调的基本理解，以及这些网络如何用于药物开发。