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Consistency principle in biological dynamical systems.
Theory in Biosciences ( IF 1.1 ) Pub Date : 2008-04-22 , DOI: 10.1007/s12064-008-0034-z
Kunihiko Kaneko 1 , Chikara Furusawa
Affiliation  

We propose a principle of consistency between different hierarchical levels of biological systems. Given a consistency between molecule replication and cell reproduction, universal statistical laws on cellular chemical abundances are derived and confirmed experimentally. They include a power law distribution of gene expressions, a lognormal distribution of cellular chemical abundances over cells, and embedding of the power law into the network connectivity distribution. Second, given a consistency between genotype and phenotype, a general relationship between phenotype fluctuations by genetic variation and isogenic phenotypic fluctuation by developmental noise is derived. Third, we discuss the chaos mechanism for stem cell differentiation with autonomous regulation, resulting from a consistency between cell reproduction and growth of the cell ensemble.

中文翻译:

生物动力系统中的一致性原则。

我们提出了生物系统不同层次之间的一致性原则。鉴于分子复制和细胞繁殖之间的一致性,可以通过实验推导出和证实细胞化学丰度的普遍统计规律。它们包括基因表达的幂律分布、细胞上细胞化学丰度的对数正态分布,以及将幂律嵌入到网络连接分布中。其次,考虑到基因型和表型之间的一致性,可以推导出遗传变异引起的表型波动与发育噪声引起的同基因表型波动之间的一般关系。第三,我们讨论了自主调控干细胞分化的混沌机制,
更新日期:2019-11-01
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