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Efficacy of Antenatal Intravenous Immunoglobulin Treatment in Pregnancies at High Risk due to Alloimmunization to Red Blood Cells
Transfusion Medicine and Hemotherapy ( IF 2.2 ) Pub Date : 2018-01-01 , DOI: 10.1159/000490154
Beate Mayer 1 , Larry Hinkson 2 , Wiebke Hillebrand 2 , Wolfgang Henrich 2 , Abdulgabar Salama 3
Affiliation  

Background: Alloimmunization to red blood cells (RBCs) may result in fetal anemia prior to 20 weeks gestation. The question as to whether early commencement of antenatal treatment with high-dose intravenous immunoglobulins (IVIG) may prevent or at least delay the development of fetal anemia in the presence of alloantibodies to RBCs is highly relevant. Patients and Results: Here we describe a patient with high-titer anti-K and two other severely affected pregnant women with a history of recurrent pregnancy loss due to high-titer anti-D or anti-D plus anti-C. Early commencement of treatment with IVIG (1 g/kg/week) resulted in prevention of intrauterine transfusion (IUT) in the former two cases, and in a significant delay of development of fetal anemia in the remaining case (26 weeks gestation). Conclusion: Based on our findings and of previously published cases, early initiation of treatment of severely alloimmunized women with IVIG (1 g/kg/week) could potentially improve the outcome of fetuses at risk.

中文翻译:

红细胞同种免疫高危妊娠产前静脉注射免疫球蛋白治疗的疗效

背景:对红细胞 (RBC) 的同种免疫可能导致妊娠 20 周前的胎儿贫血。在存在针对红细胞的同种抗体的情况下,早期开始使用高剂量静脉注射免疫球蛋白 (IVIG) 进行产前治疗是否可以预防或至少延缓胎儿贫血的发展的问题是高度相关的。患者和结果:在这里,我们描述了一名患有高滴度抗 K 的患者和另外两名因高滴度抗 D 或抗 D 加抗 C 导致反复流产的孕妇。早期开始使用 IVIG(1 g/kg/周)治疗可预防前两个病例的宫内输血(IUT),并显着延缓其余病例(妊娠 26 周)胎儿贫血的发展。结论:
更新日期:2018-01-01
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