AIM To investigate the effects of the water extracts of Danggui Shaoyao San (DGSYS) in rats used the passive avoidance task. METHODS Impairment in learning acquisition in rats was induced by colchicines, and the level of superoxide dismutase in the brain and the effects of DGSYS on the locomotor activity and pain threshold induced by colchicines were detected. RESULTS DGSYS (0.1-1.0 g/kg) attenuated the impairment of learning acquisition induced by colchicine (15 microg) and DGSYS (0.5 and 1.0 g/kg) increased the level of SOD (141 +/- 3 and 135.4 +/- 2.0) in the brain. However, DGSYS (0.1 - 1.0 g/kg) did not affect the locomotor activity and pain threshold in the rats treated with colchicines. CONCLUSION DGSYS can improve the learning acquisition deficit induced by colchicine in rats. The action mechanism of DGSYS may be involved in the increase in the level of superoxide dismutase.

中文翻译：

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当归sha药散改善了秋水仙碱诱导的大鼠学习习得障碍。

目的研究当归少药散（DGSYS）水提物对大鼠的被动回避作用。方法秋水仙碱可诱发大鼠学习障碍，并检测脑中超氧化物歧化酶水平和DGSYS对秋水仙碱引起的运动能力和疼痛阈值的影响。结果DGSYS（0.1-1.0 g / kg）减轻了秋水仙碱（15 microg）诱导的学习障碍，而DGSYS（0.5和1.0 g / kg）增加了SOD的水平（141 +/- 3和135.4 +/- 2.0） ）在大脑中。但是，DGSYS（0.1-1.0 g / kg）不会影响秋水仙碱治疗大鼠的运动能力和疼痛阈值。结论DGSYS可以改善秋水仙碱诱导的大鼠学习障碍。