The effects of prolonged fasting and refeeding on insulin secretion were examined in seven obese non-diabetic subjects. Plasma insulin and C-peptide concentrations were measured before and after fasting for 7 days, and after refeeding with a low caloric diet. Urine C-peptide excretion during 24 h was determined daily during the study period. Plasma insulin and C-peptide levels fell by about 50 percent during fasting and returned to the prefasting values after refeeding. During fasting the 24-h urine C-peptide excretion was markedly diminished; after 7 days it was less than 10 percent of the prefasting level; on refeeding a low caloric diet, it increased significantly although not to the initial basal values. It is concluded that in human obesity pancreatic insulin secretion is markedly diminished by prolonged fasting.

中文翻译：

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人体肥胖中的胰岛素分泌：长期禁食和重新喂养的影响。

在七个肥胖的非糖尿病受试者中，研究了长期禁食和补充食物对胰岛素分泌的影响。在禁食7天之前和之后以及低热量饮食重新喂养后，测量血浆胰岛素和C肽浓度。在研究期间每天测定24小时内的尿C肽排泄量。禁食期间血浆胰岛素和C肽水平下降约50％，重新喂食后恢复至禁食前的水平。禁食期间，尿液中24 C肽的排泄显着减少。7天后，它不到禁食前水平的10％；补充低热量饮食后，虽然未达到初始基础值，但显着增加。结论是，长期禁食可显着减少人肥胖症中胰腺胰岛素的分泌。