Basal plasma gastrin levels were significantly higher in obese rats induced by ventromedial hypothalamic lesions (VMH rats) than in sham-operated controls. Gastrin secretion in response to insulin hypoglycemia and a liquid diet load was higher in VMH rats than in controls. The antral gastrin concentration was also elevated in VMH rats. Pair-fed rats with VMH lesions showed increased gastrin secretion as did the non-pair-fed group. These results show that gastrointestinal hormone secretions as well as pancreatic endocrine function are abnormal in obese rats with VMH lesions. Increased gastrin secretion is probably induced by factors other then hyperphagia, such as disturbance of the autonomic nervous system due to the VMH lesions.

中文翻译：

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肥胖大鼠腹膜下丘脑病变胃泌素分泌的变化。

腹膜下丘脑损伤诱发的肥胖大鼠（VMH大鼠）的基础血浆胃泌素水平显着高于假手术对照组。VMH大鼠对胰岛素低血糖和液体饮食负荷的胃泌素分泌高于对照组。VMH大鼠的胃窦胃泌素浓度也升高。配对喂养的VMH损伤大鼠与非配对喂养的组相比，胃泌素分泌增加。这些结果表明，肥胖的VMH病变大鼠的胃肠道激素分泌以及胰腺内分泌功能均异常。胃泌素分泌增加可能是由食欲亢进以外的其他因素引起的，例如由于VMH病变引起的自主神经系统紊乱。