A novel treatment planning framework, the Relative Biological Effective Dose (RBED), for high Z nanoparticle (NP)-enhanced photon radiotherapy is developed and tested in silico for the medical exemplar of neoadjuvant (preoperative) breast cancer MV photon radiotherapy. Two different treatment scenarios, conventional and high Z NP enhanced, were explored with a custom Geant4 application that was developed to emulate the administration of a single 2 Gy fraction as part of a 50 Gy radiotherapy treatment plan. It was illustrated that there was less than a 1% difference in the dose deposition throughout the standard and high Z NP-doped adult female phantom. Application of the RBED framework found that the extent of possible biological response with high Z NP doping was great than expected via the dose deposition alone. It is anticipated that this framework will assist the scientific community in future high Z NP-enhanced in-silico, pre-clinical and clinical trials.

中文翻译：

---

使用高Z纳米粒子放射增敏剂的光子放射疗法治疗计划：相对生物有效剂量（RBED）框架。

针对高Z纳米粒子（NP）增强的光子放射疗法，开发了一种新颖的治疗计划框架，即相对生物有效剂量（RBED），并在计算机上对其进行了测试，以用于新辅助（术前）乳腺癌MV光子放射疗法的医学范例。使用定制的Geant4应用程序探索了两种不同的治疗方案，即常规和高Z NP增强，该应用程序被开发为模拟单个2 Gy组分的给药，作为50 Gy放射治疗计划的一部分。可以看出，在整个标准和高Z NP掺杂的成年女性模型中，剂量沉积的差异小于1％。RBED框架的应用发现，高Z NP掺杂可能产生的生物学反应的程度比仅通过剂量沉积所预期的要大。