Hyperuricemia, defined as the presence of elevated serum uric acid (sUA), could lead to urate deposit in joints, tendons, kidney and other tissues. Hyperuricemia as an independent risk factor was common in patients during the causation and progression of kidney disease. Uric acid is a soluble final product of endogenous and dietary purine metabolism, which is freely filtered in kidney glomeruli where approximately 90% of filtered uric acid is reabsorbed. Considerable studies have demonstrated that soluble uric acid was involved in the pathophysiology of renal arteriolopathy, tubule injury, tubulointerstitial fibrosis, as well as glomerular hypertrophy and glomerulosclerosis. In the review, we summarized the mechanistic insights of soluble uric acid related renal diseases.

高尿酸血症定义为血清尿酸（sUA）升高，可能导致尿酸盐沉积在关节，腱，肾脏和其他组织中。高尿酸血症是独立的危险因素，在肾脏疾病的病因和病情发展过程中很常见。尿酸是内源性和饮食中嘌呤代谢的可溶终产物，可在肾小球中自由过滤，其中约90％的尿酸被重吸收。大量研究表明，可溶性尿酸参与了肾动脉病变，肾小管损伤，肾小管间质纤维化以及肾小球肥大和肾小球硬化的病理生理。在这篇综述中，我们总结了与可溶性尿酸相关的肾脏疾病的机理研究。