Reconsolidation theory has supported the notion that active memory is vulnerable to the effects of an amnesic agent. An extension of reconsolidation theory posits that active memory, while necessary for creating vulnerability in memory, is not sufficient. Prediction error (i.e., when expectation is inconsistent with reality) may be a key factor in the destabilization of memory. The present study examined the role of prediction error in appetitive memory reconsolidation. Rats learned to dig in cups of scented sand to retrieve buried sweet cereal rewards. Forty-eight hours following acquisition, a single reactivation trial was given during which a prediction error or no prediction error was included. The prediction error consisted of a single extinction trial, while the no prediction error condition consisted of an additional reinforced trial. Cycloheximide (CHX; 1 mg/kg) or vehicle (VEH: distilled water; 1 mg/kg) was administered intraperitoneally immediately following reactivation. One week following reactivation, rats received 2 nonreinforced test trials. Results showed longer latencies to dig for rats that received CHX following a prediction error (CHX/PE) compared to rats that received VEH (VEH/PE) or did not receive a prediction error (CHX/NoPE or VEH/NoPE). These results add to a growing literature demonstrating that protein synthesis is necessary in appetitive memory reconsolidation only when reactivation includes a prediction error. (PsycINFO Database Record

中文翻译：

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只有当重新激活包括预测错误时，才能重新组合具有刺激性的气味，才需要蛋白质合成。

重新整合理论支持以下观点：主动记忆易受记忆删除剂的影响。重新整合理论的扩展提出，活动内存虽然不足以在内存中创建漏洞，但仍然是不够的。预测错误（即，当期望与现实不一致时）可能是导致内存不稳定的关键因素。本研究检查了预测错误在竞争性记忆重建中的作用。老鼠学会了挖杯香沙，以获取埋藏的甜谷物奖励。采集后48小时，进行了一次重新激活试验，在此期间未包含预测错误或没有预测错误。预测误差由一次灭绝试验组成，而无预测误差条件由额外的加固试验组成。活化后立即腹腔注射环己酰亚胺（CHX; 1 mg / kg）或赋形剂（VEH：蒸馏水; 1 mg / kg）。重新激活后一周，大鼠接受了2次非增强试验。结果显示，与接受VEH（VEH / PE）或未接受预测错误（CHX / NoPE或VEH / NoPE）的大鼠相比，因预测错误（CHX / PE）接受CHX的大鼠有更长的挖掘潜伏期。这些结果增加了越来越多的文献，证明只有在重新激活包括预测错误的情况下，蛋白质合成才在竞争性记忆重建中是必需的。（PsycINFO数据库记录 结果显示，与接受VEH（VEH / PE）或未接受预测错误（CHX / NoPE或VEH / NoPE）的大鼠相比，因预测错误（CHX / PE）接受CHX的大鼠有更长的挖掘潜伏期。这些结果增加了越来越多的文献，证明只有在重新激活包括预测错误的情况下，蛋白质合成才在竞争性记忆重建中是必需的。（PsycINFO数据库记录 结果显示，与接受VEH（VEH / PE）或未接受预测错误（CHX / NoPE或VEH / NoPE）的大鼠相比，因预测错误（CHX / PE）接受CHX的大鼠有更长的挖掘潜伏期。这些结果增加了越来越多的文献，证明只有在重新激活包括预测错误的情况下，蛋白质合成才在竞争性记忆重建中是必需的。（PsycINFO数据库记录