The soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein family is of vital importance for organelle communication. The complexing of cognate SNARE members present in both the donor and target organellar membranes drives the membrane fusion required for intracellular transport. In the endocytic route, SNARE proteins mediate trafficking between endosomes and phagosomes with other endosomes, lysosomes, the Golgi apparatus, the plasma membrane, and the endoplasmic reticulum. The goal of this review is to provide an overview of the SNAREs involved in endosomal and phagosomal trafficking. Of the 38 SNAREs present in humans, 30 have been identified at endosomes and/or phagosomes. Many of these SNAREs are targeted by viruses and intracellular pathogens, which thereby reroute intracellular transport for gaining access to nutrients, preventing their degradation, and avoiding their detection by the immune system. A fascinating picture is emerging of a complex transport network with multiple SNAREs being involved in consecutive trafficking routes.

中文翻译：

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内吞性和吞噬性SNARE。

可溶性N-乙基马来酰亚胺敏感因子附着蛋白受体（SNARE）蛋白家族对于细胞器通讯至关重要。存在于供体和靶细胞器质膜中的同源SNARE成员的复合物驱动细胞内运输所需的膜融合。在内吞途径中，SNARE蛋白介导内体和吞噬体与其他内体，溶酶体，高尔基体，质膜和内质网之间的运输。这项审查的目的是概述与内体和吞噬体贩运有关的SNARE。在人类中存在的38种SNARE中，有30种被鉴定为内体和/或吞噬体。其中许多SNARE都受到病毒和细胞内病原体的攻击，从而重新安排细胞内运输路线，以获取营养，防止其降解并避免被免疫系统检测。令人着迷的画面是复杂的运输网络，其中多个SNARE涉及连续的贩运路线。