当前位置: X-MOL 学术Annu. Rev. Nutr. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
GUGULIPID: a natural cholesterol-lowering agent.
Annual Review of Nutrition ( IF 8.9 ) Pub Date : 2003-03-11 , DOI: 10.1146/annurev.nutr.23.011702.073102
Nancy L Urizar 1 , David D Moore
Affiliation  

The resin of the Commiphora mukul tree has been used in Ayurvedic medicine for more than 2000 years to treat a variety of ailments. Studies in both animal models and humans have shown that this resin, termed gum guggul, can decrease elevated lipid levels. The stereoisomers E- and Z-guggulsterone have been identified as the active agents in this resin. Recent studies have shown that these compounds are antagonist ligands for the bile acid receptor farnesoid X receptor (FXR), which is an important regulator of cholesterol homeostasis. It is likely that this effect accounts for the hypolipidemic activity of these phytosteroids.

中文翻译:

GUGULIPID:一种天然的降胆固醇剂。

Commiphora mukul树的树脂已在印度草药医学中使用了2000多年,可用于治疗各种疾病。在动物模型和人类模型上的研究均表明,这种称为树胶的树脂可降低升高的脂质水平。立体异构体E-和Z-古古甾酮已被确定为该树脂的活性剂。最近的研究表明,这些化合物是胆汁酸受体法呢类X受体(FXR)的拮抗剂配体,该受体是胆固醇稳态的重要调节剂。这种作用可能解释了这些植物类固醇的降血脂活性。
更新日期:2019-11-01
down
wechat
bug