Ralstonia solanacearum is a devastating plant pathogen with a global distribution and an unusually wide host range. This bacterium can also be free-living as a saprophyte in water or in the soil in the absence of host plants. The availability of the complete genome sequence from strain GMI1000 provided the basis for an integrative analysis of the molecular traits determining the adaptation of the bacterium to various environmental niches and pathogenicity toward plants. This review summarizes current knowledge and speculates on some key bacterial functions, including metabolic versatility, resistance to metals, complex and extensive systems for motility and attachment to external surfaces, and multiple protein secretion systems. Genome sequence analysis provides clues about the evolution of essential virulence genes such as those encoding the Type III secretion system and related pathogenicity effectors. It also provided insights into possible mechanisms contributing to the rapid adaptation of the bacterium to its environment in general and to its interaction with plants in particular.

中文翻译：

---

从茄属番茄的基因组分析中学到的经验教训。

青枯雷尔氏菌是毁灭性植物病原体，具有全球分布，宿主范围异常广泛。在没有宿主植物的情况下，该细菌也可以作为腐生植物在水中或土壤中自由生活。来自菌株GMI1000的完整基因组序列的可用性为分子特性的综合分析提供了基础，这些分子特性决定了细菌对各种环境生态位的适应性以及对植物的致病性。这篇综述总结了当前的知识，并推测了一些关键的细菌功能，包括代谢的多功能性，对金属的抗性，复杂且广泛的运动性和附着于外表面的系统以及多种蛋白质分泌系统。基因组序列分析提供了有关必需毒力基因进化的线索，例如编码III型分泌系统和相关致病性效应子的那些基因。它也提供了有关可能的机制的见解，这些机制有助于使细菌快速适应其总体环境，特别是其与植物的相互作用。