Tissue engineering has the potential to redefine rehabilitation for the breast cancer patient by providing a translatable strategy that restores the postmastectomy breast mound while concomitantly obviating limitations realized with contemporary reconstructive surgery procedures. The engineering design goal is to provide a sufficient volume of viable fat tissue based on a patient's own cells such that deficits in breast volume can be abrogated. To be sure, adipose tissue engineering is in its infancy, but tremendous strides have been made. Numerous studies attest to the feasibility of adipose tissue engineering. The field is now poised to challenge barriers to clinical translation that are germane to most tissue engineering applications, namely scale-up, large animal model development, and vascularization. The innovative and rapid progress of adipose engineering to date, as well as opportunities for its future growth, is presented.

中文翻译：

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乳房组织工程。

通过提供一种可翻译的策略，组织工程学有可能重新定义乳腺癌患者的康复能力，该策略可恢复乳房切除术后的乳房丘，同时消除现代重建手术程序所带来的局限性。工程设计的目标是根据患者自己的细胞提供足够量的活脂肪组织，以消除乳房体积的不足。可以肯定的是，脂肪组织工程学还处于起步阶段，但是已经取得了长足的进步。大量研究证明了脂肪组织工程的可行性。现在，该领域已准备好挑战与大多数组织工程应用密切相关的临床翻译障碍，即扩大规模，开发大型动物模型和血管化。