The growth and remodeling of a tissue depends on certain features in the history of its mechanical environment as well as its genetic makeup. The mechanical environment influences the tissue's developing morphology, the process of simply increasing the size of existing morphological structures, and the formation of the proteins of which the tissue is constructed. The relationships between genetic information, various epigenetic mechanisms and tissue development are discussed. The developmental growth and remodeling of most structural tissues are enhanced by the use of those tissues and retarded by their disuse. The mechanical or mathematical modeling of tissue growth and development using cellular automata models and continuum mechanical models is reviewed.

中文翻译：

---

组织生长和重塑。

组织的生长和重塑取决于其机械环境及其遗传构成的历史特征。机械环境影响组织的发育形态，简单地增加现有形态结构大小的过程以及构成组织的蛋白质的形成。讨论了遗传信息，各种表观遗传机制与组织发育之间的关系。大多数结构组织的发育生长和重塑通过使用这些组织而得到增强，而由于它们的废弃而受到阻碍。审查了使用细胞自动机模型和连续体力学模型对组织生长和发育进行的机械或数学建模。