For many years, cytoplasmic intermediate filaments (IFs) were considered to be stable cytoskeletal elements contributing primarily to the maintenance of the structural and mechanical integrity of cells. However, recent studies of living cells have revealed that IFs and their precursors possess a remarkably wide array of dynamic and motile properties. These properties are in large part due to interactions with molecular motors such as conventional kinesin, cytoplasmic dynein, and myosin. The association between IFs and motors appears to account for much of the well-documented molecular cross talk between IFs and the other major cytoskeletal elements, microtubules, and actin-containing microfilaments. Furthermore, the associations with molecular motors are also responsible for the high-speed, targeted delivery of nonfilamentous IF protein cargo to specific regions of the cytoplasm where they polymerize into IFs. This review considers the functional implications of the motile properties of IFs and discusses the potential relationships between malfunctions in these motile activities and human diseases.

中文翻译：

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中间丝的动态和运动特性。

多年来，细胞质中间丝（IFs）被认为是稳定的细胞骨架元件，主要有助于维持细胞的结构和机械完整性。但是，最近对活细胞的研究表明，中频及其前体具有非常广泛的动态和运动特性。这些特性在很大程度上是由于与分子动力（例如常规驱动蛋白，胞质动力蛋白和肌球蛋白）的相互作用。中频与运动之间的联系似乎解释了中频与其他主要细胞骨架元件，微管和含肌动蛋白的微丝之间的大量文献记载的分子串扰。此外，与分子马达的关联也负责高速运动，靶向将非丝状IF蛋白货物递送至细胞质的特定区域，在该区域中它们聚合成IF。这篇综述考虑了IF的运动特性的功能含义，并讨论了这些运动活动中的故障与人类疾病之间的潜在关系。