Cells adhere to the extracellular matrix throughout most of their lifetime. This close, intimate contact with the matrix exerts an extraordinary control on the behavior of cells, determining whether they move or stay put, proliferate or remain quiescent, and even live or die. Attachment to the matrix not only enables cells to respond to soluble growth factors and cytokines but also determines the nature of the response. The integrins are a large family of receptors that attach cells to the matrix, organize their cytoskeleton, and cooperate with receptor protein tyrosine kinases to regulate cell fate. Research on integrin signaling is beginning to explain the complex and specific effects that the extracellular matrix exerts on cells.

中文翻译：

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通过联合整联蛋白/受体蛋白激酶信号传导对细胞命运的位置控制。

细胞在其整个生命周期的大部分时间内都粘附在细胞外基质上。与基质的这种紧密，紧密的接触对细胞的行为施加了非凡的控制，从而决定了细胞是移动还是保持原状，增殖还是保持静止，甚至存活或死亡。与基质的附着不仅使细胞对可溶性生长因子和细胞因子产生反应，而且还决定了反应的性质。整联蛋白是一大类受体，它们将细胞附着在基质上，组织其细胞骨架，并与受体蛋白酪氨酸激酶协同调节细胞命运。整联蛋白信号传导的研究开始解释细胞外基质对细胞的复杂和特异性作用。