Computational models of the electrical and mechanical function of the heart are reviewed. These models attempt to explain the integrated function of the heart in terms of ventricular anatomy, the structure and material properties of myocardial tissue, the membrane ion channels, and calcium handling and myofilament mechanics of cardiac myocytes. The models have established the computational framework for linking the structure and function of cardiac cells and tissue to the integrated behavior of the intact heart, but many more aspects of physiological function, including metabolic and signal transduction pathways, need to be included before significant progress can be made in understanding many disease processes.

中文翻译：

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模拟整体心脏功能。

审查了心脏电和机械功能的计算模型。这些模型试图从心室解剖结构，心肌组织的结构和材料特性，膜离子通道以及心肌细胞的钙离子处理和肌丝力学方面解释心脏的整合功能。这些模型已经建立了将心脏细胞和组织的结构和功能与完整心脏的整合行为联系起来的计算框架，但是在取得重大进展之前，还需要包括生理功能的许多其他方面，包括代谢和信号传导途径可以理解许多疾病的过程。