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THECOP9 SIGNALOSOME: Regulating Plant Development Through the Control of Proteolysis
Annual Review of Plant Biology ( IF 23.9 ) Pub Date : 2003-06-01 , DOI: 10.1146/annurev.arplant.54.031902.134847
Giovanna Serino 1 , Xing-Wang Deng
Affiliation  

The COP9 signalosome (CSN) is a multiprotein complex that was initially identified in plants as a repressor of photomorphogenesis. It is now known to play major roles in several other developmental pathways, from auxin response to flower development. Furthermore, the COP9 signalosome shares homologies with the lid sibcomplex of the proteasome and is evolutionarily conserved from fission yeast to humans. It is important for the proper development of virtually all higher eukaryotes. In recent years, significant progress has been made in unraveling the molecular, cellular, and physiological mode of action of the COP9 signalosome. This review discusses our current understanding of the COP9 signalosome function with particular emphasis on its recently defined role in modulating a wide variety of cellular processes by regulating specific protein degradation events.

中文翻译:

THECOP9 信号体:通过控制蛋白水解来调节植物发育

COP9 信号小体 (CSN) 是一种多蛋白复合物,最初在植物中被鉴定为光形态发生的抑制因子。现在已知它在其他几种发育途径中发挥重要作用,从生长素反应到花发育。此外,COP9 信号小体与蛋白酶体的盖同胞复合体具有同源性,并且在从裂殖酵母到人类的进化上是保守的。这对于几乎所有高等真核生物的正常发育都很重要。近年来,在阐明 COP9 信号小体的分子、细胞和生理作用模式方面取得了重大进展。
更新日期:2003-06-01
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