In this article, we review the evidence that dietary protein has a positive influence on bone health, reduces hip fracture risk, and promotes postfracture recovery, and we consider the molecular, cellular, and endocrine bases of the interactions that link protein and calcium metabolism, including effects via IGF-1 and PTH. In addition, we consider the roles of amino acid-sensing mechanisms in coupling dietary protein intake to metabolic change as well as the central role of calcium-sensing receptors (CaRs) in the control of calcium metabolism. Finally, we consider how recently identified broad-spectrum amino acid-sensing receptors from class 3 of the G-protein coupled receptor superfamily including, remarkably, the CaR itself may contribute to the impact of dietary protein on bone.

中文翻译：

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膳食蛋白质和骨骼健康：氨基酸敏感受体在钙代谢和骨骼稳态控制中的作用。

在本文中，我们回顾了饮食蛋白对骨骼健康，降低髋部骨折风险并促进骨折后恢复的积极影响的证据，并考虑了链接蛋白和钙代谢的相互作用的分子，细胞和内分泌基础，包括通过IGF-1和PTH产生的影响。此外，我们考虑了氨基酸传感机制在饮食蛋白质摄入与代谢变化耦合中的作用，以及钙敏感受体（CaRs）在钙代谢控制中的核心作用。最后，我们考虑最近如何从G蛋白偶联受体超家族的3类中识别出广谱氨基酸敏感受体，其中包括显着的CaR本身可能对饮食蛋白对骨骼的影响有所贡献。