P2X receptors are cation selective ion channels gated by the binding of extracellular ATP. Seven subtypes have been identified and they have widespread and overlapping distributions throughout the body. They form homo- and heterotrimeric complexes that differ in their functional properties and subcellular localization. They form part of larger signalling complexes, interacting with unrelated ion channels and other membrane and cytosolic proteins. Up- or down-regulation of their expression is associated with several disease states. This review aims to summarize recent work on the assembly and trafficking of this family of receptors.

中文翻译：

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P2X 嘌呤能受体的组装和运输（综述）。

P2X 受体是由细胞外 ATP 结合门控的阳离子选择性离子通道。已经确定了七个亚型，它们在整个身体中具有广泛和重叠的分布。它们形成功能特性和亚细胞定位不同的同源和异源三聚体复合物。它们形成较大的信号复合物的一部分，与无关的离子通道和其他膜蛋白和胞质蛋白相互作用。它们表达的上调或下调与几种疾病状态有关。本综述旨在总结最近关于该受体家族组装和贩运的工作。