Extracellular matrix (ECM) remodeling is strongly favored by the conditions occurring in the inflammatory microenvironment and can lead to pathogenic reactions directed toward the ECM itself. Several reports have described autoimmune responses to ECM molecules in patients with inflammatory diseases whose pathogenesis is not primarily related to ECM autoimmunity. This review will focus on the molecular interplay that governs ECM remodeling during tissue inflammation and will discuss how chronic inflammation can act as a driving force for the induction of autoimmune responses to ECM components as well as how the elicited autoimmunity can sustain local or induce distant tissue damage.

中文翻译：

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持久的组织炎症过程会触发对细胞外基质分子的自身免疫反应。

炎性微环境中发生的状况强烈促进细胞外基质（ECM）重塑，并可导致针对ECM本身的致病反应。几篇报道描述了炎症性疾病患者对ECM分子的自身免疫反应，其发病机理与ECM自身免疫性无关。这篇综述将关注组织炎症过程中控制ECM重塑的分子相互作用，并将讨论慢性炎症如何充当诱导对ECM成分的自身免疫反应的驱动力，以及引发的自身免疫如何维持局部或诱导远处组织损伤。