A novel tri-n-butyl(IV) derivative of 2-thiobarbituric acid (HTBA) of formula [(n-Bu)(3)Sn(TBA) H(2)O] (1) has been synthesized and characterized by elemental analysis and (119)Sn-NMR and FT-IR spectroscopic techniques. The crystal structure of complex 1 has been determined by single crystal X-ray diffraction analysis at 120(2) K. The geometry around Sn(IV) is trigonal bipyramidal. Three n-butyl groups and one oxygen atom from a deprotonated 2-thiobarbituric ligand are bonded to the metal center. The geometry is completed with one oxygen from a water molecule. Compound 1 exhibits potent, in vitro, cytotoxicity against sarcoma cancer cells (mesenchymal tissue) from the Wistar rat, polycyclic aromatic hydrocarbons (PAH, benzo[a]pyrene) carcinogenesis. In addition, the inhibition caused by 1, in the rate of lipoxygenase (LOX) catalyzed oxidation reaction of linoleic acid to hyperoxolinoleic acid, has been also kinetically and theoretically studied. The results are compared to that of cisplatin.

中文翻译：

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三正丁基锡 (IV) 与 2-硫代巴比妥酸的新型两性离子络合物的晶体结构和抗肿瘤活性。

合成了式 [(n-Bu)(3)Sn(TBA) H(2)O] (1) 的 2-硫代巴比妥酸 (HTBA) 的新型三正丁基 (IV) 衍生物，并通过元素表征分析和 (119)Sn-NMR 和 FT-IR 光谱技术。配合物 1 的晶体结构已通过 120(2) K 下的单晶 X 射线衍射分析确定。Sn(IV) 周围的几何形状是三角双锥。来自去质子化的 2-硫代巴比妥配体的三个正丁基和一个氧原子与金属中心键合。几何形状是由一个水分子中的一个氧完成的。化合物 1 对来自 Wistar 大鼠的肉瘤癌细胞（间充质组织）、多环芳烃（PAH、苯并 [a] 芘）致癌作用显示出有效的体外细胞毒性。此外，由 1 引起的抑制，在脂肪氧化酶 (LOX) 催化亚油酸氧化成高氧杂油酸的速率方面，也进行了动力学和理论研究。将结果与顺铂的结果进行比较。