当前位置: X-MOL 学术Front. Neuroendocrin. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Progesterone receptors: Form and function in brain
Frontiers in Neuroendocrinology ( IF 7.4 ) Pub Date : 2008-05-01 , DOI: 10.1016/j.yfrne.2008.02.001
Roberta Diaz Brinton 1 , Richard F Thompson , Michael R Foy , Michel Baudry , Junming Wang , Caleb E Finch , Todd E Morgan , Christian J Pike , Wendy J Mack , Frank Z Stanczyk , Jon Nilsen
Affiliation  

Emerging data indicate that progesterone has multiple non-reproductive functions in the central nervous system to regulate cognition, mood, inflammation, mitochondrial function, neurogenesis and regeneration, myelination and recovery from traumatic brain injury. Progesterone-regulated neural responses are mediated by an array of progesterone receptors (PR) that include the classic nuclear PRA and PRB receptors and splice variants of each, the seven transmembrane domain 7TMPRbeta and the membrane-associated 25-Dx PR (PGRMC1). These PRs induce classic regulation of gene expression while also transducing signaling cascades that originate at the cell membrane and ultimately activate transcription factors. Remarkably, PRs are broadly expressed throughout the brain and can be detected in every neural cell type. The distribution of PRs beyond hypothalamic borders, suggests a much broader role of progesterone in regulating neural function. Despite the large body of evidence regarding progesterone regulation of reproductive behaviors and estrogen-inducible responses as well as effects of progesterone metabolite neurosteroids, much remains to be discovered regarding the functional outcomes resulting from activation of the complex array of PRs in brain by gonadally and/or glial derived progesterone. Moreover, the impact of clinically used progestogens and developing selective PR modulators for targeted outcomes in brain is a critical avenue of investigation as the non-reproductive functions of PRs have far-reaching implications for hormone therapy to maintain neurological health and function throughout menopausal aging.

中文翻译:

黄体酮受体:大脑中的形式和功能

新数据表明,黄体酮在中枢神经系统中具有多种非生殖功能,可调节认知、情绪、炎症、线粒体功能、神经发生和再生、髓鞘形成和创伤性脑损伤的恢复。孕酮调节的神经反应由一系列孕酮受体 (PR) 介导,其中包括经典的核 PRA 和 PRB 受体及其剪接变体、七个跨膜结构域 7TMPRbeta 和膜相关 25-Dx PR (PGRMC1)。这些 PR 诱导基因表达的经典调节,同时还转导起源于细胞膜并最终激活转录因子的信号级联。值得注意的是,PR 在整个大脑中广泛表达,并且可以在每种神经细胞类型中检测到。PR 的分布超出下丘脑边界,表明孕酮在调节神经功能方面具有更广泛的作用。尽管有大量证据表明孕酮对生殖行为和雌激素诱导反应的调节以及孕酮代谢物神经类固醇的影响,但关于性腺和/或性腺激活大脑中复杂的 PR 阵列所产生的功能结果仍有许多待发现。或神经胶质衍生的黄体酮。此外,临床使用的孕激素和开发选择性 PR 调节剂对大脑目标结果的影响是一个重要的研究途径,因为 PR 的非生殖功能对激素治疗具有深远的影响,以在整个绝经期衰老过程中维持神经健康和功能。
更新日期:2008-05-01
down
wechat
bug