The remarkable success story of the therapeutic application of pooled immunoglobulin G (IgG) preparations from thousands of donors, the so-called intravenous IgG (IVIG) therapy, to patients with a variety of hematological and immunological disorders began more than half a century ago. Since then, the use of this primary blood product has increased constantly, resulting in the serious danger of shortages in supply. Despite its widespread use and therapeutic success, the mechanisms of action, especially of the anti-inflammatory activity, are only beginning to be understood. In this review, we summarize the clinical use of IVIG for different diseases and discuss recent data on the molecular mechanisms that might explain how this potent drug mediates its activity in vivo.

中文翻译：

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静脉注射免疫球蛋白的抗炎作用。

超过半个世纪以前，成千上万的捐赠者汇集了免疫球蛋白G（IgG）制剂的治疗性应用，即所谓的静脉IgG（IVIG）治疗，用于多种血液学和免疫学疾病的患者，取得了令人瞩目的成功。从那时起，这种一次血液制品的使用量一直在增加，从而导致供应短缺的严重危险。尽管其广泛使用和治疗成功，但作用机理，特别是抗炎活性的作用机理，才刚刚开始被理解。在这篇综述中，我们总结了IVIG在不同疾病中的临床应用，并讨论了有关分子机制的最新数据，这些数据可能解释了这种有效药物如何在体内介导其活性。