B lymphocyte-induced maturation protein-1 (Blimp-1), discovered 16 years ago as a transcriptional repressor of the IFNbeta promoter, plays fundamentally important roles in many cell lineages and in early development. This review focuses on Blimp-1 in lymphocytes. In the B cell lineage, Blimp-1 is required for development of immunoglobulin-secreting cells and for maintenance of long-lived plasma cells (LLPCs). Direct targets of Blimp-1 and the transcriptional cascades Blimp-1 initiates to trigger plasmacytic differentiation are described. Blimp-1 also affects the homeostasis and function of CD4(+), CD8(+), and regulatory CD4(+) T cells, and Blimp-1 levels are highest in antigen-experienced T cells. Blimp-1 attenuates T cell proliferation and survival and modulates differentiation. Roles for Blimp-1 in Th1/Th2 specification, regulatory T cell function, and CD8 differentiation and function are under investigation. Signals that induce Blimp-1 in B cells include Toll-like receptor ligands and cytokines; in T cells, T cell receptors and cytokines induce Blimp-1. In spite of some commonalities, different targets and regulators of Blimp-1 in B and T cells suggest intriguing evolutionary divergence of this regulatory machinery.

中文翻译：

---

Blimp-1在T和B淋巴细胞中的调节和功能。

B淋巴细胞诱导的成熟蛋白1（Blimp-1），在16年前被发现是IFNbeta启动子的转录阻遏物，在许多细胞谱系和早期发育中起着根本性的重要作用。这篇综述着重于淋巴细胞中的Blimp-1。在B细胞谱系中，Blimp-1是分泌免疫球蛋白的细胞发育和维持长寿浆细胞（LLPC）所必需的。描述了Blimp-1的直接靶标和Blimp-1启动以触发浆细胞分化的转录级联反应。Blimp-1还影响CD4（+），CD8（+）和调节性CD4（+）T细胞的稳态和功能，并且Blimp-1水平在经历过抗原的T细胞中最高。Blimp-1减弱T细胞的增殖和存活并调节分化。Th1 / Th2规范中Blimp-1的角色，调节性T细胞功能以及CD8的分化和功能正在研究中。在B细胞中诱导Blimp-1的信号包括Toll样受体配体和细胞因子。在T细胞中，T细胞受体和细胞因子诱导Blimp-1。尽管有一些共性，但B细胞和T细胞中Blimp-1的不同靶标和调节剂表明，这种调节机制引起了有趣的进化差异。