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Alkaloid Biosynthesis: Metabolism and Trafficking
Annual Review of Plant Biology ( IF 23.9 ) Pub Date : 2008-06-01 , DOI: 10.1146/annurev.arplant.59.032607.092730
Jörg Ziegler 1 , Peter J Facchini
Affiliation  

Alkaloids represent a highly diverse group of compounds that are related only by the occurrence of a nitrogen atom in a heterocyclic ring. Plants are estimated to produce approximately 12,000 different alkaloids, which can be organized into groups according to their carbon skeletal structures. Alkaloid biosynthesis in plants involves many catalytic steps, catalyzed by enzymes that belong to a wide range of protein families. The characterization of novel alkaloid biosynthetic enzymes in terms of structural biochemistry, molecular and cell biology, and biotechnological applications has been the focus of research over the past several years. The application of genomics to the alkaloid field has accelerated the discovery of cDNAs encoding previously elusive biosynthetic enzymes. Other technologies, such as large-scale gene expression analyses and metabolic engineering approaches with transgenic plants, have provided new insights into the regulatory architecture of alkaloid metabolism.

中文翻译:

生物碱生物合成:代谢和贩运

生物碱代表了一组高度多样化的化合物,它们仅与杂环中出现的氮原子有关。据估计,植物会产生大约 12,000 种不同的生物碱,这些生物碱可以根据它们的碳骨架结构进行分组。植物中的生物碱生物合成涉及许多催化步骤,由属于广泛蛋白质家族的酶催化。在结构生物化学、分子和细胞生物学以及生物技术应用方面对新型生物碱生物合成酶的表征是过去几年的研究重点。基因组学在生物碱领域的应用加速了编码以前难以捉摸的生物合成酶的 cDNA 的发现。其他技术,
更新日期:2008-06-01
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