Hepatitis C virus (HCV) coinfection occurs in an estimated one quarter of HIV-infected persons in Europe, Australia, and the United States. As use of highly active antiretroviral drugs has markedly reduced opportunistic infections, HCV-related liver disease has emerged as a leading cause of death. HIV infection adversely affects both the natural history and the treatment of hepatitis C. Because there are no experimental models of coinfection and because the pathogenesis of each infection is incompletely understood, how HIV infection alters hepatitis C is not clear. This review considers the epidemiology, natural history, treatment, and pathogenesis of hepatitis C in HIV-infected persons.

中文翻译：

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丙型肝炎对艾滋病感染者的挑战。

在欧洲，澳大利亚和美国，约有四分之一的HIV感染者发生丙型肝炎病毒（HCV）合并感染。由于使用高活性抗逆转录病毒药物已大大减少了机会性感染，因此与HCV相关的肝病已成为主要的死亡原因。HIV感染对自然病史和丙型肝炎的治疗均产生不利影响。由于尚无合并感染的实验模型，并且由于每种感染的发病机理尚未完全了解，因此尚不清楚HIV感染如何改变丙型肝炎。这篇综述考虑了艾滋病毒感染者中丙型肝炎的流行病学，自然史，治疗和发病机理。