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Appropriate use of cervical cancer vaccine.
Annual Review of Medicine ( IF 10.5 ) Pub Date : 2008-01-12 , DOI: 10.1146/annurev.med.59.092806.131644
Gregory D Zimet 1 , Marcia L Shew , Jessica A Kahn
Affiliation  

Human papillomavirus (HPV) is a necessary, though not sufficient, cause of cervical cancer. Two vaccines have been developed that prevent two HPV types associated with 70% of cervical cancers. One of the vaccines (a quadrivalent vaccine) also prevents two HPV types associated with 90% of genital warts. Both HPV vaccines have shown very good efficacy and safety. This review summarizes the guidelines for use of the quadrivalent vaccine published by the Advisory Committee on Immunization Practices, presents data on vaccine efficacy and safety, and gives an overview of the findings of cost-effectiveness studies. In addition, we summarize the research on the attitudes of parents and health care providers toward HPV vaccine and critically evaluate controversial and challenging issues surrounding HPV vaccination, including concerns about sexual disinhibition and potential obstacles to vaccine distribution and uptake.

中文翻译:

适当使用宫颈癌疫苗。

人乳头瘤病毒(HPV)是引起宫颈癌的必要原因,但还不够。已经开发出两种疫苗来预防与70%的宫颈癌相关的两种HPV类型。其中一种疫苗(四价疫苗)还可预防与90%的生殖器疣相关的两种HPV类型。两种HPV疫苗均显示出非常好的疗效和安全性。这篇综述总结了免疫实践咨询委员会发布的四价疫苗使用指南,提供了有关疫苗功效和安全性的数据,并概述了成本效益研究的结果。此外,我们总结了有关父母和医疗保健提供者对HPV疫苗态度的研究,并严格评估了围绕HPV疫苗接种的有争议和挑战性的问题,
更新日期:2019-11-01
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