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Corticosteroid hormones in the central stress response: Quick-and-slow
Frontiers in Neuroendocrinology ( IF 7.4 ) Pub Date : 2008-05-01 , DOI: 10.1016/j.yfrne.2007.10.002
E Ronald de Kloet 1 , Henk Karst , Marian Joëls
Affiliation  

Recent evidence shows that corticosteroid hormones exert rapid non-genomic effects on neurons in the hypothalamus and the hippocampal CA1 region. The latter depend on classical mineralocorticoid receptors which are accessible from the outside of the plasma membrane and display a 10-fold lower affinity for corticosterone than the nuclear version involved in neuroprotection. Consequently, this 'membrane' receptor could play an important role while corticosteroid levels are high, i.e. during the initial phase of the stress response. We propose that during this phase corticosterone promotes hippocampal excitability and amplifies the effect of other stress hormones. These permissive non-genomic effects may contribute to fast behavioral effects and encoding of stress-related information. The fast effects are complemented by slower glucocorticoid receptor-mediated effects which facilitate suppression of temporary raised excitability, recovery from the stressful experience and storage of information for future use.

中文翻译:

中枢应激反应中的皮质类固醇激素:快而慢

最近的证据表明,皮质类固醇激素对下丘脑和海马 CA1 区的神经元产生快速的非基因组影响。后者依赖于经典的盐皮质激素受体,这些受体可从质膜外部进入,对皮质酮的亲和力比参与神经保护的核受体低 10 倍。因此,当皮质类固醇水平高时,即在应激反应的初始阶段,这种“膜”受体可以发挥重要作用。我们建议在此阶段皮质酮促进海马兴奋性并放大其他应激激素的作用。这些宽松的非基因组效应可能有助于快速行为效应和压力相关信息的编码。
更新日期:2008-05-01
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