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An autosomal genome-wide screen for celiac disease in Bedouin families.
Genes and Immunity ( IF 5 ) Pub Date : 2007-10-19 , DOI: 10.1038/sj.gene.6364439
Y C Ding 1 , Z Weizman , B Yerushalmi , K Elbedour , C P Garner , S L Neuhausen
Affiliation  

Celiac disease is a common, familial autoimmune disease caused by exposure to gliadin in wheat, and related prolamins in barley and rye. The prevalence of the disease is approximately 1:133. Celiac disease can cause significant morbidity. The only treatment is a gluten-free diet. A genome-wide search of 405 microsatellite markers was performed on samples from 18 Bedouin families with a minimum of two cases of celiac disease. Non-parametric and parametric (including both dominant and recessive models of inheritance) linkage analyses were performed. The most significant genome-wide linkage evidence was at chromosome 3p26 with an HLod of 3.21, under the dominant model. The only other HLod or NPL greater than 2 was at 4q35, with an HLod of 2.15 under a dominant model. The region at 3p26, previously reported in two linkage analyses, harbors interleukin receptor genes, plausible candidates for celiac disease.

中文翻译:

贝都因人家庭乳糜泻的常染色体全基因筛查。

乳糜泻是一种常见的家族性自身免疫性疾病,是由于小麦中暴露于麦醇溶蛋白以及大麦和黑麦中相关的谷醇溶蛋白引起的。该病的患病率约为1:133。腹腔疾病可导致重大发病。唯一的治疗方法是无麸质饮食。对来自18个贝都因人家庭的样本进行了405个微卫星标记的全基因组搜索,其中至少有2例乳糜泻。进行了非参数和参数(包括显性和隐性继承模型)链接分析。在显性模型下,最重要的全基因组连锁证据是在染色体3p26处,HLod为3.21。唯一大于2的HLod或NPL处于4q35,在主导模型下HLod为2.15。先前在两次连锁分析中报告的3p26区域,
更新日期:2019-11-01
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