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Haplotypes of the interleukin 7 receptor alpha gene are correlated with altered expression in whole blood cells in multiple sclerosis.
Genes and Immunity ( IF 5 ) Pub Date : 2007-10-12 , DOI: 10.1038/sj.gene.6364436 F C McKay 1 , L I Swain , S D Schibeci , J P Rubio , T J Kilpatrick , R N Heard , G J Stewart , D R Booth
Genes and Immunity ( IF 5 ) Pub Date : 2007-10-12 , DOI: 10.1038/sj.gene.6364436 F C McKay 1 , L I Swain , S D Schibeci , J P Rubio , T J Kilpatrick , R N Heard , G J Stewart , D R Booth
Affiliation
IL7 regulates T cell survival, differentiation and proliferation. The alpha chain of its receptor, CD127, is polymorphic, and its haplotypes are associated with recovery from transplantation and with the autoimmune disease multiple sclerosis (MS), especially primary progressive MS (PPMS). We demonstrate that two CD127 haplotypes are highly associated with the proportion of the mRNA encoding the soluble isoform of CD127 (P
中文翻译：
白细胞介素7受体α基因的单倍型与多发性硬化症中全血细胞表达的改变有关。
IL7调节T细胞的存活，分化和增殖。其受体CD127的α链是多态性，其单倍型与移植后的恢复以及自身免疫性疾病多发性硬化症（MS），尤其是原发进行性MS（PPMS）有关。我们证明了两种CD127单倍型与编码CD127可溶性亚型的mRNA的比例高度相关（P
更新日期：2019-11-01
中文翻译：
白细胞介素7受体α基因的单倍型与多发性硬化症中全血细胞表达的改变有关。
IL7调节T细胞的存活，分化和增殖。其受体CD127的α链是多态性，其单倍型与移植后的恢复以及自身免疫性疾病多发性硬化症（MS），尤其是原发进行性MS（PPMS）有关。我们证明了两种CD127单倍型与编码CD127可溶性亚型的mRNA的比例高度相关（P
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