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Toward a hyperstructure taxonomy.
Annual Review of Microbiology ( IF 10.5 ) Pub Date : 2007-09-28 , DOI: 10.1146/annurev.micro.61.081606.103348
Vic Norris 1 , Tanneke den Blaauwen , Roy H Doi , Rasika M Harshey , Laurent Janniere , Alfonso Jiménez-Sánchez , Ding Jun Jin , Petra Anne Levin , Eugenia Mileykovskaya , Abraham Minsky , Gradimir Misevic , Camille Ripoll , Milton Saier , Kirsten Skarstad , Michel Thellier
Affiliation  

Bacterial cells contain many large, spatially extended assemblies of ions, molecules, and macromolecules, called hyperstructures, that are implicated in functions that range from DNA replication and cell division to chemotaxis and secretion. Interactions between these hyperstructures would create a level of organization intermediate between macromolecules and the cell itself. To explore this level, a taxonomy is needed. Here, we describe classification criteria based on the form of the hyperstructure and on the processes responsible for this form. These processes include those dependent on coupled transcription-translation, protein-protein affinities, chromosome site-binding by protein, and membrane structures. Various combinations of processes determine the formation, maturation, and demise of many hyperstructures that therefore follow a trajectory within the space of classification by form/process. Hence a taxonomy by trajectory may be desirable. Finally, we suggest that working toward a taxonomy based on speculative interactions between hyperstructures promises most insight into life at this level.

中文翻译:

迈向超结构分类法。

细菌细胞包含许多大型的,在空间上延伸的离子,分子和大分子装配体,称为超结构,它们涉及从DNA复制,细胞分裂到趋化性和分泌等功能。这些超结构之间的相互作用将在大分子与细胞本身之间产生一定程度的组织中间水平。要探索此级别,需要分类法。在这里,我们根据超结构的形式和负责该形式的过程来描述分类标准。这些过程包括那些依赖于偶联的转录-翻译,蛋白质-蛋白质亲和力,蛋白质的染色体位点结合以及膜结构的过程。过程的各种组合决定了形成,成熟,因此许多超结构的消失,这些超结构因此在按照形式/过程进行分类的空间内遵循一条轨迹。因此,可能需要通过轨迹进行分类。最后,我们建议基于超结构之间的推测性交互作用进行分类的工作有望在此级别上为生活提供更多见识。
更新日期:2019-11-01
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