Exocytotic release of neurotransmitters requires their accumulation inside preformed secretory vesicles. Distinct vesicular transport activities translocate classical transmitters into synaptic vesicles energized by a H+ electrochemical gradient (Delta(mu(H+))), with subtle but important differences in dependence on the electrical and chemical components. The vesicular transporters also interact with toxic compounds and drugs. They mediate neuroprotection by sequestering toxic compounds as well as neurotransmitters into vesicles, reducing their concentration in the cytosol where they may have detrimental effects. Both therapeutic agents and psychostimulants interfering with vesicular transport have yielded insight into the pathogenesis of psychiatric as well as neurodegenerative diseases. Thus, specific inhibitors have helped to characterize both the physiological role and mechanism of vesicular neurotransmitter transport.

中文翻译：

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囊泡神经递质转运蛋白是内源性和外源性有毒物质的靶标。

神经递质的胞外释放需要它们在预先形成的分泌性囊泡中积累。独特的囊泡运输活动将经典的递质转移到由H +电化学梯度（Delta（mu（H +））激发的突触小泡中，但对电和化学成分的依赖却微妙而重要。囊泡转运蛋白还与有毒化合物和药物相互作用。它们通过将有毒化合物以及神经递质螯合到囊泡中来介导神经保护作用，从而降低它们在细胞溶质中的浓度，从而可能产生有害作用。干扰水泡运输的治疗剂和精神刺激药都已使人对精神病以及神经退行性疾病的发病机理有了更深入的了解。从而，