Toll-like receptors (TLRs) enable innate immune recognition of endogenous and exogenous prototypic ligands. They also orchestrate innate and adaptive immune response to infection, inflammation, and tissue injury. Given their significance in the immune response, it is not surprising that genetic variations of TLRs can affect their function and by extension affect the response of the organism to environmental stimuli. The genetics of TLRs provides important insights in gene-environment interactions in health and disease, and it may enable scientists to assess patients' susceptibility to diseases or predict their response to treatments.

中文翻译：

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Toll样受体和Toll样受体遗传学在人类疾病中的作用。

Toll样受体（TLR）能够对内源性和外源性原型配体进行先天免疫识别。他们还精心安排对感染，炎症和组织损伤的先天性和适应性免疫反应。考虑到它们在免疫反应中的重要性，TLR的遗传变异会影响其功能并通过延伸影响生物体对环境刺激的反应就不足为奇了。TLR的遗传学为健康与疾病中的基因-环境相互作用提供了重要的见识，它可能使科学家能够评估患者对疾病的易感性或预测他们对治疗的反应。