The positioning and elaboration of ectodermal veins in the wing of Drosophila melanogaster rely on widely utilized developmental signals, including those mediated by EGF, BMP, Hedgehog, Notch, and Wnt. Analysis of vein patterning mutants, using the molecular and genetic mosaic techniques available in Drosophila, has provided important insights into how a combination of short-range and long-range signaling can pattern a simple epidermal tissue. Moreover, venation has become a powerful system for isolating and analyzing novel components in these signaling pathways. I here review the basic events of vein patterning and give examples of how changes in venation have been used to identify important features of cell signaling pathways.

中文翻译：

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果蝇的翼静脉模式和细胞间信号的分析。

果蝇果皮中外胚层静脉的定位和加工依赖于广泛使用的发育信号，包括由EGF，BMP，刺猬，Notch和Wnt介导的信号。使用果蝇中可用的分子和遗传镶嵌技术对静脉模式突变体进行分析，对短程和长程信号组合如何构成简单的表皮组织提供了重要的见识。此外，静脉已经成为分离和分析这些信号传导途径中新成分的强大系统。我在这里回顾静脉模式的基本事件，并举例说明静脉变化如何用于识别细胞信号通路的重要特征。